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hsb 2  (DSMZ)


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    DSMZ hsb 2
    Hsb 2, supplied by DSMZ, used in various techniques. Bioz Stars score: 94/100, based on 26 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/hsb 2/product/DSMZ
    Average 94 stars, based on 26 article reviews
    hsb 2 - by Bioz Stars, 2026-04
    94/100 stars

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    Image Search Results


    (A) Schematic representation of aptamer–lipid nanoparticle (LNP) formulation using a microfluidic device, followed by thiol–aptamer conjugation. (B) Hydrodynamic size and (C) polydispersity index (PDI) of MC3- and SM102-based LNPs, either non-targeting or Apt62-modified. (D) Schematic illustrating molecular beacon hybridization assay for quantifying aptamer density on LNPs. (E) Thermal melt curves of Apt62 molecular beacons at concentrations ranging from 0 to 800 nM. (F) Biolayer interferometry (BLI) sensograms of Apt62 binding to recombinant human CD4 protein. (G) BLI sensograms of Apt62-functionalized LNPs binding to recombinant human CD4 protein. Data represent mean±SD ( n = 3 for B–C).

    Journal: Drug Delivery

    Article Title: Lipid nanoparticles with aptamers enable targeted mRNA delivery to CD4⁺ T cells

    doi: 10.1080/10717544.2026.2637266

    Figure Lengend Snippet: (A) Schematic representation of aptamer–lipid nanoparticle (LNP) formulation using a microfluidic device, followed by thiol–aptamer conjugation. (B) Hydrodynamic size and (C) polydispersity index (PDI) of MC3- and SM102-based LNPs, either non-targeting or Apt62-modified. (D) Schematic illustrating molecular beacon hybridization assay for quantifying aptamer density on LNPs. (E) Thermal melt curves of Apt62 molecular beacons at concentrations ranging from 0 to 800 nM. (F) Biolayer interferometry (BLI) sensograms of Apt62 binding to recombinant human CD4 protein. (G) BLI sensograms of Apt62-functionalized LNPs binding to recombinant human CD4 protein. Data represent mean±SD ( n = 3 for B–C).

    Article Snippet: CD4 + SUPT-1 (Cat. No. CRL-1942) and CD4 - HSB-2 (Cat. No. CCL-120.1) human cell lines, Roswell Park Memorial Institute medium (RPMI-1640, Cat. No. 30-2001), and Iscove's modified Dulbecco's medium (IMDM, Cat. No. 30-2005) culture media were obtained from the American Type Culture Collection (Virginia, USA).

    Techniques: Formulation, Conjugation Assay, Modification, Hybridization, Binding Assay, Recombinant

    Evaluation of cytotoxicity of aptamer-functionalized lipid nanoparticles (LNPs). Cell viability was measured following treatment with increasing doses of luciferase mRNA-loaded LNPs formulated with either MC3 or SM102 ionizable lipids. (A) SUP-T1 cells and (B) HSB-2 cells were incubated with non-targeting LNPs or Apt62-modified LNPs for 24 hours. Data represent mean±SD ( n = 4).

    Journal: Drug Delivery

    Article Title: Lipid nanoparticles with aptamers enable targeted mRNA delivery to CD4⁺ T cells

    doi: 10.1080/10717544.2026.2637266

    Figure Lengend Snippet: Evaluation of cytotoxicity of aptamer-functionalized lipid nanoparticles (LNPs). Cell viability was measured following treatment with increasing doses of luciferase mRNA-loaded LNPs formulated with either MC3 or SM102 ionizable lipids. (A) SUP-T1 cells and (B) HSB-2 cells were incubated with non-targeting LNPs or Apt62-modified LNPs for 24 hours. Data represent mean±SD ( n = 4).

    Article Snippet: CD4 + SUPT-1 (Cat. No. CRL-1942) and CD4 - HSB-2 (Cat. No. CCL-120.1) human cell lines, Roswell Park Memorial Institute medium (RPMI-1640, Cat. No. 30-2001), and Iscove's modified Dulbecco's medium (IMDM, Cat. No. 30-2005) culture media were obtained from the American Type Culture Collection (Virginia, USA).

    Techniques: Luciferase, Incubation, Modification

    (A) eGFP expression in SUP-T1 (CD4⁺) and HSB2 (CD4⁻) cells following treatment with mRNA-loaded LNPs formulated with MC3 or SM102, either non-targeting, Apt62-modified (25:1 or 100:1), or anti-human CD4 mAb-conjugated. (B) Representative flow cytometry histograms showing eGFP signal in live, singlet-gated in SUP-T1 (CD4⁺) and HSB2 (CD4⁻) cells that were untreated (non-transfected) or treated with SM102-Apt62:100 or SM102 anti-human CD4 mAb-modified LNPs. (C) Quantification of mean fluorescence intensity (MFI) of SUP-T1 (CD4⁺) and HSB2 (CD4⁻) populations corresponding to panel (B). Data represent mean±SD ( n = 4). Statistical significance was determined using two-way ANOVA followed by Tukey's multiple comparisons test; **** p < 0.0001, *** p < 0.001, ** p < 0.01, ####p < 0.0001 versus corresponding CD4⁺ population.

    Journal: Drug Delivery

    Article Title: Lipid nanoparticles with aptamers enable targeted mRNA delivery to CD4⁺ T cells

    doi: 10.1080/10717544.2026.2637266

    Figure Lengend Snippet: (A) eGFP expression in SUP-T1 (CD4⁺) and HSB2 (CD4⁻) cells following treatment with mRNA-loaded LNPs formulated with MC3 or SM102, either non-targeting, Apt62-modified (25:1 or 100:1), or anti-human CD4 mAb-conjugated. (B) Representative flow cytometry histograms showing eGFP signal in live, singlet-gated in SUP-T1 (CD4⁺) and HSB2 (CD4⁻) cells that were untreated (non-transfected) or treated with SM102-Apt62:100 or SM102 anti-human CD4 mAb-modified LNPs. (C) Quantification of mean fluorescence intensity (MFI) of SUP-T1 (CD4⁺) and HSB2 (CD4⁻) populations corresponding to panel (B). Data represent mean±SD ( n = 4). Statistical significance was determined using two-way ANOVA followed by Tukey's multiple comparisons test; **** p < 0.0001, *** p < 0.001, ** p < 0.01, ####p < 0.0001 versus corresponding CD4⁺ population.

    Article Snippet: CD4 + SUPT-1 (Cat. No. CRL-1942) and CD4 - HSB-2 (Cat. No. CCL-120.1) human cell lines, Roswell Park Memorial Institute medium (RPMI-1640, Cat. No. 30-2001), and Iscove's modified Dulbecco's medium (IMDM, Cat. No. 30-2005) culture media were obtained from the American Type Culture Collection (Virginia, USA).

    Techniques: Expressing, Modification, Flow Cytometry, Transfection, Fluorescence

    (A) Representative ex vivo IVIS images of major organs collected 6 h post-injection from mice treated with saline, MC3 or SM102 LNPs (non-targeting or Apt62:75), or SM102 anti-mouse/human CD4 mAb-conjugated LNPs. (B) Quantification of normalized luminescence in the liver. (C) Quantification of normalized luminescence in spleen. (D) Percentage of spleen-to-liver luminescence ratio. Data represent mean±SD ( n = 4). Statistical significance was determined using one-way ANOVA followed by Tukey’s multiple comparisons test; **** p < 0.0001, *** p < 0.001, ** p < 0.01.

    Journal: Drug Delivery

    Article Title: Lipid nanoparticles with aptamers enable targeted mRNA delivery to CD4⁺ T cells

    doi: 10.1080/10717544.2026.2637266

    Figure Lengend Snippet: (A) Representative ex vivo IVIS images of major organs collected 6 h post-injection from mice treated with saline, MC3 or SM102 LNPs (non-targeting or Apt62:75), or SM102 anti-mouse/human CD4 mAb-conjugated LNPs. (B) Quantification of normalized luminescence in the liver. (C) Quantification of normalized luminescence in spleen. (D) Percentage of spleen-to-liver luminescence ratio. Data represent mean±SD ( n = 4). Statistical significance was determined using one-way ANOVA followed by Tukey’s multiple comparisons test; **** p < 0.0001, *** p < 0.001, ** p < 0.01.

    Article Snippet: CD4 + SUPT-1 (Cat. No. CRL-1942) and CD4 - HSB-2 (Cat. No. CCL-120.1) human cell lines, Roswell Park Memorial Institute medium (RPMI-1640, Cat. No. 30-2001), and Iscove's modified Dulbecco's medium (IMDM, Cat. No. 30-2005) culture media were obtained from the American Type Culture Collection (Virginia, USA).

    Techniques: Ex Vivo, Injection, Saline

    Assessment of organ indices and systemic cytokine markers 6 h postinjection. (A) Liver-to-body weight ratio. (B) Spleen-to-body weight ratio. (C) Serum IL-6 levels. (D) Serum TNF- α levels. (E) Serum ALT levels. The mice were treated with saline, MC3 or SM102 LNPs (nontargeting or Apt62:75), or SM102 anti-mouse CD4 mAb-conjugated LNPs. Data represent the mean±SD ( n = 4). Statistical significance was determined using one-way ANOVA followed by Tukey’s multiple comparisons test; ** p < 0.01.

    Journal: Drug Delivery

    Article Title: Lipid nanoparticles with aptamers enable targeted mRNA delivery to CD4⁺ T cells

    doi: 10.1080/10717544.2026.2637266

    Figure Lengend Snippet: Assessment of organ indices and systemic cytokine markers 6 h postinjection. (A) Liver-to-body weight ratio. (B) Spleen-to-body weight ratio. (C) Serum IL-6 levels. (D) Serum TNF- α levels. (E) Serum ALT levels. The mice were treated with saline, MC3 or SM102 LNPs (nontargeting or Apt62:75), or SM102 anti-mouse CD4 mAb-conjugated LNPs. Data represent the mean±SD ( n = 4). Statistical significance was determined using one-way ANOVA followed by Tukey’s multiple comparisons test; ** p < 0.01.

    Article Snippet: CD4 + SUPT-1 (Cat. No. CRL-1942) and CD4 - HSB-2 (Cat. No. CCL-120.1) human cell lines, Roswell Park Memorial Institute medium (RPMI-1640, Cat. No. 30-2001), and Iscove's modified Dulbecco's medium (IMDM, Cat. No. 30-2005) culture media were obtained from the American Type Culture Collection (Virginia, USA).

    Techniques: Saline

    eGFP expression in SUP-T1 (CD4⁺) and HSB2 (CD4⁻) cells following transfection with SM102 LNPs functionalized with AutoNA-predicted aptamers (Apt62, Apt54, Apt72, Apt121) at a 100:1 ratio. Data represent the mean±SD ( n = 4). Statistical significance was determined using two-way ANOVA followed by Tukey’s multiple comparisons test; **** p < 0.0001.

    Journal: Drug Delivery

    Article Title: Lipid nanoparticles with aptamers enable targeted mRNA delivery to CD4⁺ T cells

    doi: 10.1080/10717544.2026.2637266

    Figure Lengend Snippet: eGFP expression in SUP-T1 (CD4⁺) and HSB2 (CD4⁻) cells following transfection with SM102 LNPs functionalized with AutoNA-predicted aptamers (Apt62, Apt54, Apt72, Apt121) at a 100:1 ratio. Data represent the mean±SD ( n = 4). Statistical significance was determined using two-way ANOVA followed by Tukey’s multiple comparisons test; **** p < 0.0001.

    Article Snippet: CD4 + SUPT-1 (Cat. No. CRL-1942) and CD4 - HSB-2 (Cat. No. CCL-120.1) human cell lines, Roswell Park Memorial Institute medium (RPMI-1640, Cat. No. 30-2001), and Iscove's modified Dulbecco's medium (IMDM, Cat. No. 30-2005) culture media were obtained from the American Type Culture Collection (Virginia, USA).

    Techniques: Expressing, Transfection